image

Nano Technology for Better Antibiotics

 

Introduction

 

Rebiotics Rx is a startup company focused on repurposing of FDA approved antibiotics by innovative formulations to fight antibiotic resistant bacteria.

According to the World Health Organization (WHO) antimicrobial resistance (AMR) is a leading global health threat jeopardizing the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. In addition, without effective antibiotics, the success of major surgery and cancer chemotherapy would be compromised. The Centers for Disease Control and Prevention (CDC) reports that each year in the United States, at least two million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections.

Indeed, a lot of research is invested in finding novel antibiotics to fight these bacteria. Still, introducing novel antibiotics from the lab to patients is a long and expensive process.
At Rebiotics Rx, we significantly simplify this development, making it faster and cheaper with increased chances of success. We identify existing antibiotics that are of limited use due to disadvantages that may be overcome by suitable delivery systems. As a result, old antibiotics that are chemically available at a clinical grade and have known mode of action may quickly reach clinical trials and eventually fight AMR.

 

The Technology

 

The lead product of Rebiotics Rx is Nano-mupirocin (1, 2). Nano-mupirocin is a PEGylated nano-liposomal formulation of the antibiotic mupirocin. Mupirocin has a unique mode of action, not shared by any other available antibiotic. It is active against pathogens defined as “urgent and serious threats” to public health, such as Neisseria gonorrhea, methicillin resistant Staphylococcus aureus (MRSA), and Streptococcus pneumonia. However, its short half-life in circulation prevents its parenteral use and limits it to topical one. Reformulation of mupirocin by the nanoliposomes increases substantially the systemic exposure to mupirocin and prolongs its half-life, thereby enabling the parenteral activity of mupirocin and practically resulting in a novel antibiotic with demonstrated efficacy in relevant animal models.

 

Inventors

 
Emeritus Yechezkel (Chezy) Barenholz

Prof. Barenholz is the head of the Liposome and Membrane Research Lab at the Hebrew University-Hadassah Medical School, Jerusalem, and the Daniel G. Miller Professor in Cancer Research at the Hebrew University of Jerusalem. He has been on the faculty at Hebrew University since 1968 and has been a visiting Professor at leading Universities around the world. His current research focuses on the development of drugs and nano-drugs based on drug delivery systems best exemplified by the anticancer drug Doxil®, the first liposomal drug and nano-drug to be approved by the FDA (1995). Prof. Barenholz is an author of >400 scientific publications and is a co-inventor in > 45 approved patent families. He is a founder of five start-up companies: Moebious, PolyPid, LipoCure, Ayana and Rebiotics Rx. He received many national and International awards including Honorary Doctorate degree from the Technical University of Denmark (2012) and the 2012 founders award of the International Controlled Release Society.

Professor Emeritus Amiram Goldblum

Prof. Goldblum is a principal investigator and a Professor Emeritus at the Hebrew University of Jerusalem. He is the head of Molecular Modeling and Drug Discovery at the Institute for Drug Research, School of Pharmacy. Prof. Goldblum received his Ph.D. in Organic Chemistry at the Hebrew University, followed by Postdoctoral studies of theoretical Chemistry at CNRS Paris, Pomona College California, and Stanford University. Prof. Goldblum joined the Medicinal Chemistry department of the Hebrew University in 1979 where he developed and applied theoretical approaches and algorithms for drug discovery. In 2000, Prof. Goldblum won the first award of the ACS Computers in Chemistry division in a contest of “Emerging technologies” for his novel algorithm to solve extremely complex combinatorial problems. This algorithm, later named “Iterative Stochastic Elimination” (ISE), has been extremely effective in the discovery of novel drugs by Prof. Goldblum and his team in diverse fields such as Obesity, Diabetes, Cancer, Immunology, Alzheimer’s Disease and Toxicology. ISE also enabled the discovery of mupirocin as a candidate for systemic delivery by liposomes.

Dr. Ahuva Cern

In parallel to her role as Rebiotics CSO, Dr. Cern is a researcher at the Lab of Membrane and Liposome Research at the Hebrew University. Previously, Dr. Cern was an associate director at Pharmos LTD. She then became the director of the formulation development lab at Nextar Chempharma Solutions, where she managed many formulation development projects for pharma and biotech companies. Dr. Cern received her Ph.D. from the Hebrew University, working at the lab of Prof. Barenholz and Prof. Goldblum at the Dept. of Biochemistrsy. Her Ph.D. thesis focused on computational models for the identification of drugs suitable for liposomal delivery.

 

Management

 
Dr. Guy Cinamon (Ph.D.), VP R&D

Dr. Cinamon has a vast experience in leading early stage drug development. After a post- doctorate fellowship at the University of California, San Francisco, Dr. Cinamon joined Teva Pharmaceutical Industries where he was a Director and held a Project Champion position. In this role he led many early stage projects of both auto-immune and cancer related indications, overseeing all aspects of drug development. He next moved to Quiet Therapeutics, where he held a position of VP Pre-Clinical Development & GM, leading the development of a targeted drug against cancer, based on nanoparticles. Dr. Cinamon received his Ph.D. in Immunology from the Weizmann Institute of Science.

Dr. Ahuva Cern (Ph.D.), CSO

Read more…

 

Board of Directors

 
Dr. Liana Patt (Ph.D., MBA), Chair

Dr. Patt is the CEO of Integra Holdings. Read more...

Mr. Lior Buchman (CPA)

Mr. Buchman is the CFO of Integra Holdings. Read more...

 

Contact Us

 

Mail: info@rebioticsrx.com | Tel: +972-(0)54-424-7524

Address: Rebiotic Rx LTD Hi-Tech Campus,
Givat Ram, Jerusalem, Israel POB 39135 Zip 91390